COVID-19 is offered to be treated with cellular inhalation

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Scientists at the Shanghai Public Health Clinical Center and Jinyintan Hospital in Wuhan are planning to launch a pilot clinical study of inhalation by stem cell waste products.

We are talking about exosomes – bubble-like small particles that release all types of cells into the surrounding fluids. They are needed for the intercellular transfer of various proteins or microRNAs. Such exosomes are also secreted by mesenchymal stem cells, which are proposed to be used in the treatment of severe coronavirus pneumonia.

Scientists emphasize that the intravenous administration of living stem cells (not exosomes), which is also now being studied by various scientific teams, may carry the risks of mutations and the development of cancer. This is not observed in the treatment with aerosolized cells.

“Since the acute respiratory distress syndrome (ARDS) in COVID-19 is believed to be the result of an imbalance in cytokines and other molecules involved in inflammatory responses, it makes sense to use approaches to mitigate these responses. A number of studies have been conducted that suggested the effectiveness of MSCs for the treatment of ARDS. Since some of the functions are realized due to the molecules secreted by these cells, it was proposed to use not them, but exosomes containing these molecules, – explained to Izvestia acting. Andrei Vasin, Director of the Institute of Biomedical Systems and Biotechnology, Peter the Great St. Petersburg Polytechnic University.

The experts emphasize that, in general, the available data on the use of exosomes in patients with COVID-19 looks interesting, and such an approach may be promising. However, there are still unanswered questions related to the dose of such drugs, the route and frequency of administration, recipient groups, interactions with other treatment methods, and so on. Therefore, research in this direction must be continued.

Read more in the Izvestia article:

Breath to the rescue: COVID-19 is offered to be treated with cellular inhalation

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